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Medications · Energy & nutritional
Hydroxocobalamin
Long-acting B12 form prescribed in select clinical contexts.
What it does
What Hydroxocobalamin is and why doctors prescribe it.
Hydroxocobalamin is a B12 form with a longer half-life than cyanocobalamin and a different metabolic profile than methylcobalamin. Doctors prescribe it for select B12-deficiency contexts, methylation-pathway considerations, and where the patient or physician prefers its kinetics or conversion path.
How it works
Mechanism in plain English.
Hydroxocobalamin is converted intracellularly to methylcobalamin and adenosylcobalamin (the body's two active B12 cofactor forms). Its longer half-life produces more sustained tissue levels per injection compared to cyanocobalamin.
How long it's been studied
Research history.
Hydroxocobalamin has been clinically used since the 1960s. It's an FDA-approved antidote for cyanide poisoning at high doses (Cyanokit). At standard B12-replacement doses, compounded hydroxocobalamin is dispensed under 503A.
Dosing
Clinical context for the prescribing doctor.
Doctor-prescribed. Injectable hydroxocobalamin at 1 mg/mL (1,000 mcg/mL) is commonly dispensed for subcutaneous or intramuscular administration. Frequency depends on indication and the patient's response.
This page is informational, not a dispensing aid. Hydroxocobalamin is dispensed only on a patient-specific prescription written by a licensed doctor for an identified patient. Compounded drugs are not FDA-approved and should not be evaluated using branded-drug trial data. Availability varies by state and prescribed medication.
How to access Hydroxocobalamin through RonanRx
Three paths.
Doctors can prescribe compounded Hydroxocobalamin for individual patients through RonanRx. Patients with a doctor can sign up to receive their prescription. Patients without a doctor can learn how the referral works.
Patient with a doctor
Sign up to receive your prescription.
If your doctor has already prescribed Hydroxocobalamin, sign up so we can prepare and ship your medication. The signup wizard collects intake and connects you to the prescribing workflow.
Patient without a doctor
Get referred by a partner clinic.
RonanRx prescribes through partner clinics — we don't initiate prescriptions on this site. Read how the referral process works and how to find a partner clinic in your state.