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Medications · Sexual health
Bremelanotide / PT-141
Melanocortin receptor agonist, FDA-approved as Vyleesi.
What it does
What Bremelanotide / PT-141 is and why doctors prescribe it.
Bremelanotide (PT-141) is FDA-approved as Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women. Compounded variants are prescribed off-label for select male and female sexual-health contexts under doctor supervision.
How it works
Mechanism in plain English.
PT-141 is a melanocortin receptor agonist (primarily MC4R) that acts centrally — in the brain — rather than peripherally on the cardiovascular system. The mechanism is distinct from PDE-5 inhibitors: it modulates central sexual-arousal pathways rather than peripheral blood flow.
How long it's been studied
Research history.
Bremelanotide development spans the 2000s; FDA approval as Vyleesi came in 2019. Off-label use in male sexual health contexts has accumulated clinical experience. Compounded preparations are dispensed under 503A.
Dosing
Clinical context for the prescribing doctor.
Doctor-prescribed. Subcutaneous compounded PT-141 is typically dispensed at 1.75 mg/dose for women and at lower or comparable strengths for men, with use timed before anticipated activity. Side effects (nausea, flushing, blood-pressure changes) inform dose-finding.
This page is informational, not a dispensing aid. Bremelanotide / PT-141 is dispensed only on a patient-specific prescription written by a licensed doctor for an identified patient. Compounded drugs are not FDA-approved and should not be evaluated using branded-drug trial data. Availability varies by state and prescribed medication.
How to access Bremelanotide / PT-141 through RonanRx
Three paths.
Doctors can prescribe compounded Bremelanotide / PT-141 for individual patients through RonanRx. Patients with a doctor can sign up to receive their prescription. Patients without a doctor can learn how the referral works.
Patient with a doctor
Sign up to receive your prescription.
If your doctor has already prescribed Bremelanotide / PT-141, sign up so we can prepare and ship your medication. The signup wizard collects intake and connects you to the prescribing workflow.
Patient without a doctor
Get referred by a partner clinic.
RonanRx prescribes through partner clinics — we don't initiate prescriptions on this site. Read how the referral process works and how to find a partner clinic in your state.
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