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Medications · Metabolic & weight
Low-Dose Naltrexone (LDN)
Naltrexone at compounded micro-doses for off-label use.
What it does
What Low-Dose Naltrexone (LDN) is and why doctors prescribe it.
Naltrexone is an FDA-approved opioid antagonist (50 mg standard dose) for alcohol- and opioid-use disorder. Low-dose naltrexone (LDN) at compounded micro-strengths (1.5–4.5 mg) is prescribed off-label by doctors for select autoimmune, chronic-pain, and metabolic indications where clinical evidence and experience support trial use.
How it works
Mechanism in plain English.
At low doses, naltrexone briefly blocks opioid receptors and may upregulate endogenous opioid (endorphin, enkephalin) production and immune-modulatory effects. Mechanism of action in autoimmune and inflammatory conditions is still being characterized. Effects differ qualitatively from standard-dose naltrexone.
How long it's been studied
Research history.
Standard-dose naltrexone was approved by the FDA in 1984. Low-dose use has been studied since the 1980s in HIV-era research and more recently in fibromyalgia, Crohn's disease, multiple sclerosis, and metabolic contexts. Compounded LDN is dispensed under 503A on doctor prescription.
Dosing
Clinical context for the prescribing doctor.
Doctor-prescribed off-label. Compounded LDN is typically initiated at 0.5–1.5 mg nightly and titrated up to 3–4.5 mg nightly. Your doctor selects strength and titration schedule based on indication and tolerance. Many patients take it at bedtime to align with endogenous opioid rhythms.
This page is informational, not a dispensing aid. Low-Dose Naltrexone (LDN) is dispensed only on a patient-specific prescription written by a licensed doctor for an identified patient. Compounded drugs are not FDA-approved and should not be evaluated using branded-drug trial data. Availability varies by state and prescribed medication.
How to access Low-Dose Naltrexone (LDN) through RonanRx
Three paths.
Doctors can prescribe compounded Low-Dose Naltrexone (LDN) for individual patients through RonanRx. Patients with a doctor can sign up to receive their prescription. Patients without a doctor can learn how the referral works.
Patient with a doctor
Sign up to receive your prescription.
If your doctor has already prescribed Low-Dose Naltrexone (LDN), sign up so we can prepare and ship your medication. The signup wizard collects intake and connects you to the prescribing workflow.
Patient without a doctor
Get referred by a partner clinic.
RonanRx prescribes through partner clinics — we don't initiate prescriptions on this site. Read how the referral process works and how to find a partner clinic in your state.
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