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Medications · Metabolic & weight
Naltrexone-Bupropion Combination
Compounded alternative to FDA-approved Contrave.
What it does
What Naltrexone-Bupropion Combination is and why doctors prescribe it.
The naltrexone-bupropion combination is FDA-approved as Contrave for chronic weight management. Compounded variants are prescribed where the patient needs custom dosing, alternative excipients, or where the manufactured supply isn't appropriate.
How it works
Mechanism in plain English.
Bupropion is a norepinephrine-dopamine reuptake inhibitor that affects appetite-regulating circuits in the hypothalamus. Naltrexone (at low- to mid-dose) blocks an inhibitory feedback loop that normally limits bupropion's effect on those circuits. The combined mechanism reduces appetite and food cravings.
How long it's been studied
Research history.
The combination received FDA approval in 2014. Bupropion alone has been clinically used since 1985, naltrexone since 1984. Compounded variants are dispensed under 503A.
Dosing
Clinical context for the prescribing doctor.
Doctor-prescribed and titrated. Compounded combinations are typically dosed twice daily in titration patterns that match the FDA-approved schedule. Your doctor selects starting strength and titration cadence; side effects (nausea, headache, insomnia) inform pacing.
This page is informational, not a dispensing aid. Naltrexone-Bupropion Combination is dispensed only on a patient-specific prescription written by a licensed doctor for an identified patient. Compounded drugs are not FDA-approved and should not be evaluated using branded-drug trial data. Availability varies by state and prescribed medication.
How to access Naltrexone-Bupropion Combination through RonanRx
Three paths.
Doctors can prescribe compounded Naltrexone-Bupropion Combination for individual patients through RonanRx. Patients with a doctor can sign up to receive their prescription. Patients without a doctor can learn how the referral works.
Patient with a doctor
Sign up to receive your prescription.
If your doctor has already prescribed Naltrexone-Bupropion Combination, sign up so we can prepare and ship your medication. The signup wizard collects intake and connects you to the prescribing workflow.
Patient without a doctor
Get referred by a partner clinic.
RonanRx prescribes through partner clinics — we don't initiate prescriptions on this site. Read how the referral process works and how to find a partner clinic in your state.