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Medications · Hormone optimization
Pregnenolone
Upstream precursor to all major steroid hormones.
What it does
What Pregnenolone is and why doctors prescribe it.
Pregnenolone is the steroid synthesized from cholesterol that sits upstream of every other steroid hormone — DHEA, progesterone, cortisol, aldosterone, the sex hormones. Doctors prescribe compounded pregnenolone for select cases where hormone-precursor support is part of the clinical plan, often alongside DHEA and other steroid-axis interventions.
How it works
Mechanism in plain English.
As the master precursor, pregnenolone enters the steroid synthesis pathway and is converted by tissue-specific enzymes into downstream hormones. Direct neuroactive effects on GABA and NMDA receptors have also been characterized. Compounded oral capsules at prescribed strengths let the doctor calibrate replacement.
How long it's been studied
Research history.
Pregnenolone has been studied since the 1940s, with renewed interest in the 1990s as steroid-pathway research expanded. Research includes work in cognition, mood, and neuroactive-steroid signaling. Like DHEA, it's sold as a supplement at low strengths and compounded as a prescription at higher precision.
Dosing
Clinical context for the prescribing doctor.
Doctor-prescribed. Compounded capsule strengths typically range from 10 mg to 100 mg daily, selected by the prescribing doctor based on the clinical picture and labs. RonanRx prepares each prescription as written.
This page is informational, not a dispensing aid. Pregnenolone is dispensed only on a patient-specific prescription written by a licensed doctor for an identified patient. Compounded drugs are not FDA-approved and should not be evaluated using branded-drug trial data. Availability varies by state and prescribed medication.
How to access Pregnenolone through RonanRx
Three paths.
Doctors can prescribe compounded Pregnenolone for individual patients through RonanRx. Patients with a doctor can sign up to receive their prescription. Patients without a doctor can learn how the referral works.
Patient with a doctor
Sign up to receive your prescription.
If your doctor has already prescribed Pregnenolone, sign up so we can prepare and ship your medication. The signup wizard collects intake and connects you to the prescribing workflow.
Patient without a doctor
Get referred by a partner clinic.
RonanRx prescribes through partner clinics — we don't initiate prescriptions on this site. Read how the referral process works and how to find a partner clinic in your state.